Ecological evolution of salmonids

For the first time, ecological evolution of salmonid fishes is analyzed using the method of historical biogeography, considering formation of ecology and reproductive biology for these species under planetary climatic and geological changes.Climate cooling in the Cenozoic and associated reconstruction of the food base for salmonids had a major impa

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Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.

An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV.This virus survival gear evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling.Th

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Drug discovery by a basic research scientist

I was fortunate to do my military service during the Vietnam era as a medical officer at the National Institutes of Health (NIH) in Bethesda, Maryland.My first research at NIH was concerned with making a variety of optical measurements on nucleic acid bases and proteins, including single crystal spectra in linearly polarized light and near infrared

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