The curvature of the NURBS curve varies along its trajectory, therefore, the commonly used feedrate-planning method, which based on the acceleration/deceleration (Acc/Dec) model, is difficult to be directly applied in CNC machining of a NURBS curve.To address this problem, a feedrate-planning method based on the critical constraint curve of the fee
Ecological evolution of salmonids
For the first time, ecological evolution of salmonid fishes is analyzed using the method of historical biogeography, considering formation of ecology and reproductive biology for these species under planetary climatic and geological changes.Climate cooling in the Cenozoic and associated reconstruction of the food base for salmonids had a major impa
Coronary angiography and percutaneus coronary intervention in the elderly
Objetive: Determine the effectiveness and short term security of the coronary angiography and percutaneos coronary Jeans intervention in the elderly.Method: Descriptive retrospective Study with the 5715 patients to whom coronary angiography was made in the CIMEQ, between 1998 and 2009, taking itself as it shows the 1933 greater ones of 60 years.The
Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.
An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV.This virus survival gear evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling.Th
Drug discovery by a basic research scientist
I was fortunate to do my military service during the Vietnam era as a medical officer at the National Institutes of Health (NIH) in Bethesda, Maryland.My first research at NIH was concerned with making a variety of optical measurements on nucleic acid bases and proteins, including single crystal spectra in linearly polarized light and near infrared